Amgen vs Pfizer: Business Model & Financial Comparison 2026
Amgen · Healthcare / Drug Manufacturers - General·Pfizer · Healthcare / Drug Manufacturers - General
Financial Comparison
| Metric | AMGNAmgen | PFEPfizer |
|---|---|---|
| Market Cap | $207.87B | N/A |
| Revenue (TTM) | $37.22B | $63.32B |
| Revenue Growth | 5.8% | 5.4% |
| Gross Margin | 71.4% | 74.8% |
| Operating Margin | 33.8% | 31.6% |
| Net Margin | 21.0% | 11.8% |
| Return on Equity | 101.3% | 8.3% |
| P/E (Trailing) | 26.8x | 19.1x |
| P/E (Forward) | 16.4x | 8.8x |
| Free Cash Flow | $7.44B | $12.38B |
| Cash | $12.04B | $13.08B |
| Total Debt | $57.32B | $64.73B |
Data sourced from Yahoo Finance. Green highlights indicate better performance for that metric. Use the interactive tool for real-time data.
Business Model Comparison
Amgen
Amgen Inc. stands as a leading company in Healthcare. Generating $36.75 billion in annual revenue (growing 8.6% year-over-year) and carrying a market capitalization of $198.16 billion, the company has cemented its position as a foundational player in the global Drug Manufacturers - General landscape. Under the leadership of its leadership team, Amgen Inc. continues to execute on a multi-year strategic vision that balances growth investment with s…
Full Amgen analysis →Pfizer
Pfizer Inc. stands as a leading company in Healthcare. Generating $62.58 billion in annual revenue (growing -1.2% year-over-year) and carrying a market capitalization of $151.30 billion, the company has cemented its position as a foundational player in the global Drug Manufacturers - General landscape. Under the leadership of its leadership team, Pfizer Inc. continues to execute on a multi-year strategic vision that balances growth investment wit…
Full Pfizer analysis →SWOT Analysis Comparison
Strengths
Amgen
- With a market capitalization of $198.16B, Amgen Inc. is one of the largest companies in its sector, providing the scale advantages of brand recognition, supplier leverage, and capital access that smal
- Amgen Inc.'s gross margin of 70.8% is well above industry averages, reflecting pricing power, operational efficiency, or a high-value product mix. The operating margin of 30.5% demonstrates discipline
- A return on equity of 106.1% demonstrates that Amgen Inc. generates strong returns from shareholder capital, a hallmark of companies with durable competitive advantages.
Pfizer
- With a market capitalization of $151.30B, Pfizer Inc. is one of the largest companies in its sector, providing the scale advantages of brand recognition, supplier leverage, and capital access that sma
- Pfizer Inc.'s gross margin of 75.8% is well above industry averages, reflecting pricing power, operational efficiency, or a high-value product mix. The operating margin of 23.9% demonstrates disciplin
- Pfizer Inc. generated $13.43B in free cash flow, providing financial flexibility to invest in growth initiatives, return capital to shareholders, or strengthen the balance sheet.
Weaknesses
Amgen
- With a debt-to-equity ratio of 640.3, Amgen Inc. carries significant debt relative to equity. While manageable given its cash flow, elevated leverage limits financial flexibility and increases vulnera
Pfizer
- Pfizer Inc.'s debt-to-equity ratio of 78.0 indicates meaningful financial leverage. Total debt stands at $67.65B against $13.60B in cash and equivalents.
- Year-over-year revenue declined 1.2%, raising questions about demand for Pfizer Inc.'s core offerings and requiring management to articulate a credible recovery path.
Opportunities
Amgen
- Amgen Inc. operates in the Drug Manufacturers - General segment of the broader Healthcare sector, which represents a $12 trillion global healthcare market by 2030. Even modest share gains in this envi
- Emerging markets — particularly India (1.4B people, rapidly growing middle class), Southeast Asia (700M people), and Sub-Saharan Africa — represent significant untapped addressable markets for Amgen I
- Earnings growth of 112.1% YoY demonstrates Amgen Inc.'s ability to convert revenue growth into shareholder value. Analysts project continued earnings expansion driven by operating leverage as fixed co
Pfizer
- Pfizer Inc. operates in the Drug Manufacturers - General segment of the broader Healthcare sector, which represents a $12 trillion global healthcare market by 2030. Even modest share gains in this env
- Emerging markets — particularly India (1.4B people, rapidly growing middle class), Southeast Asia (700M people), and Sub-Saharan Africa — represent significant untapped addressable markets for Pfizer
- With $13.60B in cash and strong free cash flow generation, Pfizer Inc. is well-positioned to pursue strategic acquisitions that expand its capabilities, customer base, or geographic reach.
Threats
Amgen
- Global economic slowdowns, inflation, or rising interest rates can reduce consumer and enterprise spending. Amgen Inc.'s revenue is not fully insulated from macroeconomic cycles, and a recession scena
- Increasing government regulation — particularly data privacy laws (GDPR, CCPA), antitrust enforcement, and trade restrictions — poses compliance costs and potential restrictions on Amgen Inc.'s busine
- Competition for skilled technology, engineering, and management talent remains intense. High employee turnover or inability to attract top talent could slow innovation and execution — particularly cri
Pfizer
- Global economic slowdowns, inflation, or rising interest rates can reduce consumer and enterprise spending. Pfizer Inc.'s revenue is not fully insulated from macroeconomic cycles, and a recession scen
- Increasing government regulation — particularly data privacy laws (GDPR, CCPA), antitrust enforcement, and trade restrictions — poses compliance costs and potential restrictions on Pfizer Inc.'s busin
- Competition for skilled technology, engineering, and management talent remains intense. High employee turnover or inability to attract top talent could slow innovation and execution — particularly cri
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Open Comparison ToolAmgen vs Pfizer: FAQ
- Is Amgen bigger than Pfizer?
- Both companies are significant players in their respective markets. See the financial comparison table above for current market capitalization data.
- Which has better profit margins — Amgen or Pfizer?
- Amgen has higher net profit margins (21.0%) compared to Pfizer (11.8%). Gross and operating margins are compared in the table above.
- What sectors do Amgen and Pfizer operate in?
- Amgen operates in the Healthcare sector (Drug Manufacturers - General). Pfizer operates in the Healthcare sector (Drug Manufacturers - General).
- How does Amgen's revenue compare to Pfizer's?
- Amgen generates $37.22B in annual revenue (TTM) while Pfizer generates $63.32B. Pfizer is the larger company by revenue as of 2026.