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Company > Adverum Biotechnologies Inc: Business Model, SWOT Analysis, and Competitors 2023

Adverum Biotechnologies Inc: Business Model, SWOT Analysis, and Competitors 2023

Published: Feb 21, 2023

Inside This Article


    In this blog article, we will delve into Adverum Biotechnologies Inc, a leading biotechnology company, and explore its business model, conduct a SWOT analysis, and identify its competitors. Adverum Biotechnologies is known for its innovative gene therapy solutions that aim to treat serious eye diseases. By analyzing its business model, strengths, weaknesses, opportunities, and threats, we can gain a comprehensive understanding of the company's position in the market. Additionally, we will examine the competitive landscape to identify other players in the biotechnology industry that Adverum Biotechnologies is up against.

    What You Will Learn:

    • The ownership structure of Adverum Biotechnologies Inc and who holds controlling stakes in the company.
    • The mission statement of Adverum Biotechnologies Inc and the goals and values that drive its operations.
    • The various revenue streams and business strategies employed by Adverum Biotechnologies Inc to generate profits.
    • An in-depth explanation of Adverum Biotechnologies Inc's Business Model Canvas, highlighting key components and their interrelationships.
    • An overview of the major competitors of Adverum Biotechnologies Inc in the biotechnology industry.
    • A comprehensive SWOT analysis of Adverum Biotechnologies Inc, examining its strengths, weaknesses, opportunities, and threats in the market.

    Who owns Adverum Biotechnologies Inc?

    Major institutional owners

    Adverum Biotechnologies Inc. (NASDAQ: ADVM) is a leading clinical-stage gene therapy company focused on developing novel treatments for serious ocular diseases. As of the latest available information, the company's ownership is primarily held by major institutional investors.

    One of the largest institutional owners of Adverum is BlackRock, a renowned global investment management corporation. According to SEC filings, BlackRock holds a significant stake in the company, with ownership exceeding 10% of the outstanding shares. This demonstrates their confidence in Adverum's potential and their commitment to supporting its growth.

    Another prominent institutional owner is Vanguard Group, an investment management company known for its diverse portfolio. Vanguard Group also holds a substantial position in Adverum, indicating their belief in the company's prospects.

    In addition to BlackRock and Vanguard Group, other notable institutional investors with significant ownership in Adverum include State Street Corporation, Fidelity Management & Research Company, and Capital Research Global Investors. These institutions play a crucial role in the biotech company's success and contribute to its stability and long-term growth.

    Insider ownership

    Apart from institutional investors, Adverum Biotechnologies Inc. also has insiders who hold ownership stakes in the company. Insider ownership can be a positive sign, as it aligns the interests of company leaders with those of shareholders. It demonstrates their confidence in the business and its ability to deliver value to investors.

    As of the latest available data, members of Adverum's executive team and board of directors collectively hold a significant ownership interest in the company. This includes individuals such as the CEO, CFO, and other key executives. Insider ownership enhances transparency and accountability, as these individuals have a vested interest in the company's performance and are motivated to drive its success.

    Retail investors

    While institutional and insider ownership dominate Adverum Biotechnologies Inc.'s ownership structure, retail investors also play a crucial role. These individual investors, often referred to as retail or individual shareholders, can include both experienced traders and everyday investors.

    Retail investors can participate in Adverum's ownership by purchasing shares through brokerage accounts or investment platforms. This allows them to have a direct stake in the company and benefit from its potential growth.

    The participation of retail investors in Adverum's ownership not only provides additional capital but also contributes to the diversity of the shareholder base. It reflects the widespread interest and support for the company among individual investors who believe in its innovations and long-term prospects.

    In conclusion, Adverum Biotechnologies Inc. is primarily owned by major institutional investors, with significant positions held by companies like BlackRock and Vanguard Group. The company also has insiders, including members of its executive team and board of directors, who hold ownership stakes. Additionally, retail investors have the opportunity to participate in the ownership of Adverum through the purchase of shares. This diverse ownership structure reflects the widespread confidence and support for the company's mission and potential.

    What is the mission statement of Adverum Biotechnologies Inc?

    Mission Statement of Adverum Biotechnologies Inc

    The mission statement of Adverum Biotechnologies Inc is centered around their commitment to developing gene therapies that can transform the lives of patients with serious ocular diseases. With a strong focus on innovation and cutting-edge biotechnology, Adverum strives to deliver groundbreaking treatments that address the underlying causes of these diseases, ultimately aiming to improve the quality of life for patients and their families.

    Adverum Biotechnologies Inc firmly believes in the power of gene therapy to revolutionize the treatment landscape, particularly for ocular diseases that have limited or no available treatment options. By harnessing the potential of their proprietary vector platform, Adverum is dedicated to developing and commercializing novel therapies that can significantly impact patients' lives.

    The company's mission extends beyond the development of therapies alone. Adverum is committed to establishing strong partnerships and collaborations with key stakeholders including patients, healthcare providers, and advocacy groups. By fostering these relationships, Adverum aims to gain valuable insights and input to ensure that their therapies effectively address the needs of patients and are accessible to those who need them.

    Adverum Biotechnologies Inc is dedicated to conducting rigorous scientific research and clinical trials to demonstrate the safety and efficacy of their gene therapies. They strive to meet the highest standards of quality and compliance, working closely with regulatory authorities to obtain the necessary approvals to bring their therapies to market.

    In summary, the mission statement of Adverum Biotechnologies Inc encapsulates their commitment to revolutionizing the treatment of ocular diseases through innovative gene therapies. By developing transformative treatments, fostering collaborations, and upholding the highest scientific and regulatory standards, Adverum aims to make a lasting impact on the lives of patients and their families.

    How does Adverum Biotechnologies Inc make money?

    Revenue Streams of Adverum Biotechnologies Inc

    Adverum Biotechnologies Inc generates its revenue through various channels within the biotechnology industry. The company primarily focuses on developing gene therapies to address genetic diseases that currently have limited treatment options. Here are the primary revenue streams that contribute to Adverum Biotechnologies' financial success:

    1. Collaborations and Licensing Agreements

    Adverum Biotechnologies collaborates with other biopharmaceutical companies and research institutions to advance its gene therapy platforms. These collaborations often involve licensing agreements, where Adverum licenses its proprietary technologies and expertise to partners in exchange for upfront and milestone payments, as well as royalties on any resulting commercialized products. These collaborations provide a significant source of revenue for the company while leveraging its innovative gene therapy platforms.

    2. Research and Development Funding

    As a leading biotechnology company, Adverum Biotechnologies actively pursues research and development (R&D) activities to advance its pipeline of gene therapy candidates. Through strategic partnerships with government agencies, non-profit organizations, and foundations, Adverum secures research grants, funding, and awards to support its R&D efforts. These funds play a crucial role in enabling the company to conduct preclinical and clinical studies, furthering the development of potential gene therapy treatments.

    3. Licensing of Intellectual Property

    Adverum Biotechnologies holds a valuable portfolio of intellectual property (IP) rights, including patents, trademarks, and trade secrets, which protect its innovative technologies and discoveries. The company generates revenue by licensing these IP assets to other companies operating in the biotechnology and pharmaceutical sectors. Through licensing agreements, Adverum ensures that its intellectual property is appropriately utilized, while earning royalties or one-time payments from the licensees.

    4. Milestone Payments and Royalties

    As Adverum Biotechnologies progresses its gene therapy candidates through clinical trials and regulatory approval processes, it often enters into agreements with pharmaceutical companies for the commercialization of its therapies. These agreements typically involve milestone payments, which are triggered upon achieving specific development, regulatory, or commercialization milestones. Additionally, Adverum may receive royalties based on the net sales of the licensed products, providing a long-term revenue stream as the therapies reach the market.

    5. Strategic Partnerships and Equity Investments

    Adverum Biotechnologies actively seeks strategic partnerships with other biotechnology and pharmaceutical companies to leverage their expertise, resources, and distribution capabilities. These partnerships may involve equity investments, where the partner company acquires a stake in Adverum, providing immediate financial support and potential future returns. Such collaborations not only offer financial benefits but also facilitate knowledge sharing and accelerated development of gene therapies.

    In conclusion, Adverum Biotechnologies Inc generates revenue through a combination of collaborations, licensing agreements, research funding, intellectual property licensing, milestone payments, royalties, strategic partnerships, and equity investments. These diverse revenue streams enable the company to continue its efforts in developing innovative gene therapies while ensuring financial stability and growth.

    Adverum Biotechnologies Inc Business Model Canvas Explained


    The business model canvas is a strategic management tool that provides a visual representation of how a company creates, delivers, and captures value. In this section, we will dive into the business model canvas of Adverum Biotechnologies Inc, a leading biotechnology company in the field of gene therapy.

    Key Partnerships

    Adverum Biotechnologies Inc relies on strategic partnerships to drive its success in the highly competitive biotechnology industry. The company collaborates with academic institutions, research organizations, and other biotech companies to access cutting-edge technology, expertise, and resources. These partnerships enable Adverum Biotechnologies Inc to accelerate the development and commercialization of its gene therapy products.

    Key Activities

    The key activities of Adverum Biotechnologies Inc revolve around the research, development, and commercialization of gene therapy treatments. The company invests heavily in research and development to discover innovative gene therapy approaches and advance their pipeline of therapeutic candidates. Additionally, Adverum Biotechnologies Inc conducts preclinical and clinical trials to evaluate the safety and efficacy of its gene therapy products. These activities are crucial in obtaining regulatory approvals and bringing transformative treatments to patients.

    Value Proposition

    Adverum Biotechnologies Inc's value proposition lies in its ability to provide innovative gene therapy solutions that address unmet medical needs. The company aims to revolutionize the treatment of inherited retinal diseases, ocular diseases, and other genetic disorders through its cutting-edge technology platform. By offering potential cures or significant improvements in patients' quality of life, Adverum Biotechnologies Inc delivers value to both patients and healthcare providers.

    Customer Segments

    Adverum Biotechnologies Inc primarily targets patients suffering from inherited retinal diseases, ocular diseases, and other genetic disorders. These individuals are often seeking better treatment options to manage their conditions and improve their visual function. Healthcare providers, including ophthalmologists and geneticists, also form a critical customer segment for Adverum Biotechnologies Inc. These professionals play a vital role in diagnosing and treating patients, making them key stakeholders in the adoption of gene therapy solutions.


    To reach its customers, Adverum Biotechnologies Inc utilizes a multi-channel approach. The company leverages direct sales representatives to engage with healthcare providers and educate them about its gene therapy products. Additionally, Adverum Biotechnologies Inc employs digital marketing strategies to raise awareness among patients and their families. Through conferences, scientific publications, and collaborations, the company also disseminates its research findings to the scientific community.

    Revenue Streams

    Adverum Biotechnologies Inc generates revenue primarily through the sale of its gene therapy products. As the company progresses through clinical trials and obtains regulatory approvals, it can start commercializing its therapies and generating sales. Additionally, Adverum Biotechnologies Inc may enter into licensing or partnership agreements, resulting in milestone payments, royalties, or upfront fees. These revenue streams support the company's continued research and development efforts.

    Key Resources

    The key resources of Adverum Biotechnologies Inc include its talented workforce, scientific expertise, intellectual property, and state-of-the-art manufacturing facilities. The company's research and development capabilities, fueled by its dedicated team of scientists and clinicians, drive innovation in the gene therapy field. Adverum Biotechnologies Inc's robust intellectual property portfolio protects its inventions and provides a competitive advantage in the market. Moreover, the company's manufacturing facilities ensure the production of high-quality gene therapy products at scale.


    Understanding the business model canvas of Adverum Biotechnologies Inc sheds light on how the company creates, delivers, and captures value in the biotechnology sector. Through strategic partnerships, innovative research and development, and a multi-channel approach, Adverum Biotechnologies Inc aims to transform the lives of patients suffering from genetic disorders. By focusing on key activities, customer segments, and revenue streams, the company positions itself for long-term success in the rapidly evolving field of gene therapy.

    Which companies are the competitors of Adverum Biotechnologies Inc?

    Competitors of Adverum Biotechnologies Inc

    Adverum Biotechnologies Inc operates in the highly competitive biotechnology industry, where numerous companies strive to develop innovative therapies and treatments. Some of the key competitors that Adverum Biotechnologies Inc faces include:

    1. Sarepta Therapeutics: Sarepta Therapeutics is a leading biopharmaceutical company focused on developing precision genetic medicines for rare diseases. They specialize in RNA-targeted therapies and have a strong pipeline of potential treatments that overlap with Adverum Biotechnologies Inc's focus areas.

    2. Spark Therapeutics: Spark Therapeutics is known for its expertise in gene therapy. They focus on developing treatments for genetic diseases, including inherited retinal diseases, which is an area of interest for Adverum Biotechnologies Inc as well. Spark Therapeutics' innovative gene therapy products pose direct competition to Adverum's gene-based therapies.

    3. Regenxbio Inc: Regenxbio Inc is a clinical-stage biotechnology company that specializes in developing gene therapies for various genetic disorders. Their pipeline includes treatments for retinal diseases, spinal muscular atrophy, and other rare conditions, making them a strong competitor to Adverum Biotechnologies Inc.

    4. Applied Genetic Technologies Corporation (AGTC): AGTC is a clinical-stage biotechnology company that focuses on developing gene-based therapies for rare eye diseases, including inherited retinal diseases. With a similar target patient population as Adverum Biotechnologies Inc, AGTC is a notable competitor in the race to bring effective treatments to market.

    5. Biogen Inc: Biogen is a well-established biotechnology company that focuses on developing therapies for neurological disorders. While their primary focus may differ from Adverum Biotechnologies Inc, there can be potential overlap in areas such as ophthalmology, making Biogen a competitor to watch out for.

    These are just a few examples of the competitors Adverum Biotechnologies Inc faces in its pursuit of developing innovative gene therapies and treatments. The biotechnology landscape is dynamic and ever-evolving, with new players emerging constantly. Adverum Biotechnologies Inc must stay vigilant, continuously innovate, and demonstrate the efficacy and safety of its products to maintain a competitive edge in the market.

    Adverum Biotechnologies Inc SWOT Analysis


    • Strong pipeline: Adverum Biotechnologies Inc has a robust pipeline of gene therapy candidates targeting various ophthalmic diseases. With a focus on developing transformative treatments, the company's strong pipeline positions it well for future growth and success in the biotechnology industry.

    • Innovative technology platform: Adverum Biotechnologies Inc is known for its cutting-edge technology platform, which allows for efficient and targeted delivery of gene therapies. This platform provides a competitive advantage, as it enables the company to develop therapies with improved efficacy and safety profiles compared to traditional approaches.

    • Strategic partnerships: The company has established strategic partnerships with leading pharmaceutical and biotechnology companies, including Regeneron Pharmaceuticals. These partnerships not only provide Adverum with additional resources and expertise but also validate the value of its technology platform and pipeline.


    • Limited product portfolio: Adverum Biotechnologies Inc currently has a limited product portfolio, with most of its candidates still in the early stages of development. This lack of diversification exposes the company to higher risks, as the success of its pipeline candidates will determine its future revenue streams.

    • Regulatory challenges: As a biotechnology company, Adverum faces the regulatory challenges inherent in the development and commercialization of gene therapies. The regulatory landscape for these therapies is evolving, and any delays or setbacks in obtaining regulatory approvals could significantly impact the company's timelines and financial performance.


    • Growing demand for gene therapies: The increasing prevalence of genetic diseases and the limited treatment options available create a significant opportunity for Adverum Biotechnologies Inc. The market for gene therapies is expected to grow rapidly, providing the company with a favorable environment to commercialize its pipeline candidates and generate substantial revenue.

    • Expansion into new therapeutic areas: While Adverum's current focus is on ophthalmic diseases, there is a potential for the company to expand into new therapeutic areas. By leveraging its technology platform and scientific expertise, Adverum can explore other disease areas that could benefit from gene therapy interventions, further diversifying its product portfolio.


    • Intense competition: The biotechnology industry is highly competitive, with numerous companies vying to develop and commercialize gene therapies. Adverum Biotechnologies Inc faces the risk of being outpaced or outmaneuvered by competitors who may have greater resources or more advanced technologies.

    • Intellectual property challenges: Protecting intellectual property is crucial for biotechnology companies, as it ensures exclusivity and market advantage. Adverum may face challenges in defending its patents and intellectual property rights against potential infringement or legal disputes, which could impact its ability to fully capitalize on its technology and pipeline.

    • Market volatility and economic conditions: Adverum Biotechnologies Inc is susceptible to market volatility and economic conditions, as it relies on investor confidence and funding to support its research and development activities. Economic downturns or fluctuations in the capital markets could impact the company's ability to secure necessary funding or attract new investors.

    Key Takeaways

    • Adverum Biotechnologies Inc is owned by various institutional investors and individual shareholders, with no single majority owner.
    • The mission statement of Adverum Biotechnologies Inc is to develop and deliver gene therapies that can transform the lives of patients suffering from serious ocular diseases.
    • Adverum Biotechnologies Inc generates revenue primarily through collaborations and partnerships with pharmaceutical companies, as well as through license fees and milestone payments.
    • The Business Model Canvas of Adverum Biotechnologies Inc outlines key elements such as customer segments, value proposition, channels, customer relationships, revenue streams, key resources, key activities, key partnerships, and cost structure.
    • Some of the competitors of Adverum Biotechnologies Inc in the gene therapy space include companies like Spark Therapeutics, bluebird bio, and uniQure.

    Please note that this information is based on general knowledge and may not be up to date. It is always recommended to conduct thorough research for accurate and current information.


    In conclusion, Adverum Biotechnologies Inc is a biotechnology company with a mission to develop gene therapies for patients suffering from serious eye diseases. The company aims to improve the lives of these patients by providing innovative treatments. Adverum Biotechnologies Inc generates revenue through partnerships, collaborations, and licensing agreements, as well as through research grants and milestone payments. The company's Business Model Canvas helps to visualize its key activities, resources, and revenue streams. As for competitors, companies such as Spark Therapeutics, Regenxbio, and Nightstar Therapeutics are prominent players in the gene therapy industry. Finally, a SWOT analysis of Adverum Biotechnologies Inc highlights its strengths in cutting-edge research and development, opportunities in the growing gene therapy market, but also acknowledges weaknesses and threats that the company must navigate to ensure future success. Overall, Adverum Biotechnologies Inc is a promising player in the biotech industry, with an ambitious mission and a strong focus on innovation and patient care.


    What are the products of adverum biotechnologies?

    Adverum Biotechnologies is a clinical-stage gene therapy company that focuses on developing novel medicines to treat serious ocular and rare diseases. Their lead product candidate is ADVM-022, a gene therapy for the treatment of wet age-related macular degeneration (wet AMD). ADVM-022 is designed to deliver a sustained release of aflibercept, a commonly used anti-VEGF protein, to the eye, reducing the need for frequent injections. Adverum is also developing other gene therapy candidates such as ADVM-032 for the treatment of diabetic retinopathy and ADVM-053 for the treatment of hereditary angioedema.

    Why is SWOT analysis outdated?

    While SWOT analysis is a widely used and popular tool for strategic planning, it has several limitations that make it less effective and outdated in certain contexts. Here are some reasons why SWOT analysis may be considered outdated:

    1. Lack of prioritization: SWOT analysis does not provide a clear mechanism for prioritizing the identified strengths, weaknesses, opportunities, and threats. It treats all factors equally, which can lead to confusion and ineffective decision-making.

    2. Overemphasis on internal factors: SWOT analysis primarily focuses on internal factors (strengths and weaknesses) and external factors (opportunities and threats) without considering the dynamic and complex relationships between them. This narrow perspective may overlook crucial interdependencies and fail to capture the broader business environment.

    3. Limited in-depth analysis: SWOT analysis tends to provide a superficial understanding of the factors being assessed. It does not offer a systematic and thorough analysis of each component, often leading to shallow insights and overlooking critical details.

    4. Lack of flexibility: SWOT analysis assumes that factors fit neatly into predefined categories, which may not always be the case. This rigidity limits its adaptability to complex and rapidly changing business environments.

    5. Lack of forward-looking approach: SWOT analysis typically focuses on the current situation and past performance, neglecting the future outlook. In today's dynamic business landscape, a more forward-looking approach is necessary to anticipate and respond to emerging trends and challenges.

    6. Subjectivity and bias: SWOT analysis heavily relies on subjective judgments, personal biases, and individual perspectives, which can lead to inconsistent and unreliable results. It lacks a structured framework for gathering and analyzing data objectively.

    7. Alternative tools available: Over time, several alternative strategic planning tools and frameworks have emerged that provide more comprehensive and sophisticated analysis. These tools, such as PESTEL analysis, Porter's Five Forces, or scenario planning, offer more detailed insights into specific aspects of a business.

    While SWOT analysis can still be useful in certain contexts, especially for smaller businesses or quick assessments, its limitations make it less suitable for complex and dynamic environments. It is recommended to combine SWOT analysis with other tools to gain a more holistic understanding of the business and its strategic decisions.

    What is SWOT analysis examples?

    SWOT analysis is a strategic planning tool used to evaluate the strengths, weaknesses, opportunities, and threats of a business or organization. Here are some examples of each component:


    1. Strong brand reputation
    2. Skilled and experienced workforce
    3. Advanced technology infrastructure
    4. Efficient supply chain management
    5. High customer satisfaction rates


    1. Limited financial resources
    2. Lack of market differentiation
    3. Inadequate employee training programs
    4. Poor online presence
    5. Dependence on a single supplier


    1. Emerging market trends and demand
    2. Expansion into new geographic markets
    3. Strategic partnerships and collaborations
    4. Introduction of innovative products or services
    5. Growing consumer interest in sustainability


    1. Intense competition from rivals
    2. Economic downturns and market fluctuations
    3. Changing government regulations
    4. Rapidly evolving technology landscape
    5. Negative public perception or reputation damage

    These are just a few examples, and the actual SWOT analysis would vary depending on the specific business or organization being analyzed.

    What is the SWOT analysis and other analysis?

    SWOT analysis is a strategic planning tool used to evaluate the strengths, weaknesses, opportunities, and threats of a business or organization. It helps in identifying the internal and external factors that can impact the success of a project or venture. Here is a breakdown of each component of SWOT analysis:

    1. Strengths: These are the positive attributes of a business or organization that give it a competitive advantage. It could be a strong brand image, skilled workforce, superior technology, financial stability, or any other internal factors that contribute to success.

    2. Weaknesses: These are the internal factors that hinder the success of a business or organization. It could be a lack of resources, outdated technology, poor management, limited market presence, or any other aspect that puts the business at a disadvantage.

    3. Opportunities: These are external factors that can be leveraged to create growth and success. It could be emerging markets, changing consumer trends, technological advancements, favorable government policies, or any other external factor that presents potential opportunities for the business.

    4. Threats: These are external factors that pose challenges or risks to the business. It could be intense competition, economic downturns, changing regulations, disruptive technologies, or any other factor that can negatively impact the business.

    Apart from SWOT analysis, there are several other types of analysis used in business and strategic planning. Some of them include:

    1. PESTLE analysis: This analysis examines the political, economic, social, technological, legal, and environmental factors affecting a business or industry.

    2. Porter's Five Forces analysis: This framework assesses the competitive forces within an industry, including the threat of new entrants, bargaining power of suppliers and buyers, threat of substitute products, and intensity of competitive rivalry.

    3. Value chain analysis: This analysis identifies the primary and support activities within a business, and analyzes how they contribute to the creation of value for customers.

    4. Financial analysis: This involves evaluating the financial health and performance of a business by examining its financial statements, ratios, and other financial indicators.

    5. Market analysis: This analysis focuses on understanding the target market, customers, competitors, and market trends to inform marketing and sales strategies.

    These various analyses help organizations in understanding their internal and external environments, making informed decisions, and developing effective strategies to achieve their goals.

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